RNA Details
Disease Name
heart failure
Tissue
heart
RNA Symbol
mir-21a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
immunofluorescence; PCR etc.
Target
NA
Pathway
NA
PubMed ID
Title
MiR-21 promotes fibrosis in an acute cardiac allograft transplantation model
Year
2016
Function
Overexpression of miR-21 in this monocyte cell line activated a fibrotic gene programme and promoted monocyte-to-fibrocyte transition together with activation of chemokine (c-c) motif ligand 2 (monocyte chemoattractant protein 1) via the phosphatase and tensin homologue/activator protein 1 regulatory axis.